I don't see the scientific evidence in the literature that would cause people any concern, said Kaminski.

How Is Titanium Dioxide Made?

There is some evidence that ingested titanium dioxide does not completely exit the body. A 2015 review of animal studies and a few human studies suggests titanium dioxide can get absorbed into the bloodstream and expose other organs to damage.

Lithopone is rather nontoxic, due to the insolubility of its components. It has been used in medicine as a radiocontrast agent. Lithopone is allowed to be in contact with foodstuffs in the US and Europe.^[1]